2023.01- ??????????中國科學(xué)院廣州生物醫(yī)藥與健康研究院 ???研究員
2013.08-2022.12 ???中國科學(xué)院廣州生物醫(yī)藥與健康研究院 ???副研究員
2010.08-2013.07 ???北京大學(xué)化學(xué)與分子工程學(xué)院 ???????????博士后
2005.09-2010.07 ???南開大學(xué)化學(xué)學(xué)院????????????????????? 博士
2001.09-2005.07 ???南開大學(xué)化學(xué)學(xué)院 ?????????????????????學(xué)士
(1)碳?xì)滏I官能化反應(yīng)用于雜環(huán)化合物的合成方法研究;
(2)異腈/一氧化碳參與的不對稱反應(yīng)研究;
(3)計(jì)算化學(xué)用于反應(yīng)機(jī)理的研究;
(4)藥物分子合成工藝的改進(jìn);
(5)抗肺癌、抗肺結(jié)核藥物開發(fā)。
2.???? 呼吸疾病國家重點(diǎn)實(shí)驗(yàn)室自主課題項(xiàng)目(SKLRD-Z-202014,以Skp1為靶標(biāo)的抗肺癌藥物分子的合成和生物活性研究,2019年至2022年,20萬元,主持,結(jié)題)
3.???? 廣東省自然科學(xué)基金面上項(xiàng)目(2020A1515011428,鈀催化的不對稱亞胺基化反應(yīng)研究,2019年至2022年,10萬元,主持,結(jié)題)
4.???? 國家自然科學(xué)基金面上項(xiàng)目(21772198,鈀催化的不對稱亞胺基化反應(yīng)研究,2018年至2021年,76萬元,主持,結(jié)題)
5.???? 中國科學(xué)院青年創(chuàng)新促進(jìn)會(2015292,人才項(xiàng)目,2015年至2017年,60萬元,主持,結(jié)題)
6.???? 國家自然科學(xué)基金青年科學(xué)基金項(xiàng)目(21402203,過渡金屬催化的雙碳?xì)滏I的羰基化反應(yīng),2015年至2017年,25萬元,主持,結(jié)題)
7.???? 國家自然科學(xué)基金面上項(xiàng)目(21672215,吲哚-2-酮-3-螺噻嗪酮類化合物的抗結(jié)核活性研究,2017年至2020年,65萬元,參與,結(jié)題)
8.???? 廣州再生醫(yī)學(xué)與健康廣東省實(shí)驗(yàn)室基礎(chǔ)研究與國際合作部科研項(xiàng)目(2018GZR110105017,抗金黃色葡萄球菌的藥物研發(fā),2019年至2021年,150萬元,參與,結(jié)題)
1.????? Yu Luo, Xilong Wang, Qianwen Liu, Yimiao He, Shuang Luo*, and Qiang Zhu*, Palladium-catalyzed alkyne hydrocarbonylation under atmospheric pressure of carbon monoxide in the presence of hydrosilane. Green Chem. 2023, 25, 1120.
2.????? Xilong Wang, Yu Luo, Jing Li, Chaoqin Wang, Qianwen Liu, Yimiao He, Shuang Luo* and Qiang Zhu*, Parallel Kinetic Resolution through Palladium-Catalyzed Enantioselective Cycloimidoylation: En Route to Divergent N-Heterocycles Bearing a Quaternary Stereogenic Center. ACS Catal. 2022, 12, 14918.
3.????? Ting Yu, Zhong-Qiu Li, Jing Li, Sidi Cheng, Jiali Xu, Jun Huang, Yu-Wu Zhong*, Shuang Luo* and Qiang Zhu*, Palladium-Catalyzed Modular Synthesis of Enantioenriched Pyridohelicenes through Double Imidoylative Cyclization. ACS Catal. 2022, 12, 13034
4.????? Yu Luo, Xilong Wang, Weiming Hu, Yan Peng, Chaoqin Wang, Ting Yu, Sidi Cheng, Jing Li, Yimiao He, Chunfang Gan, Shuang Luo* and Qiang Zhu*, Inherently Chiral 6,7-Diphenyldibenzo[e,g][1,4]diazocine: Enantioselective Synthesis and Application as a Ligand Platform. CCS Chem. 2022, 10.31635/ccschem.022.202201901.
5.????? Sidi Cheng, Yu Luo, Ting Yu, Jing Li, Chunfang Gan, Shuang Luo* and Qiang Zhu*, Palladium-Catalyzed Four-Component Cascade Imidoyl-Carbamoylation of Unactivated Alkenes. ACS Catal. 2022, 12, 837.
6.????? Huaanzi Hu, Ting Yu, Sidi Cheng, Jing Li, Chunfang Gan, Shuang Luo* and Qiang Zhu*, Palladium-Catalyzed Tandem Heck/Carbonylation/Aminocarbonylation En Route to Chiral Heterocyclic α-Ketoamides. Org. Chem. Front. 2022, 9, 939.
7.????? Yu Luo, Sidi Cheng, Yan Peng, Xilong Wang, Jing Li, Chunfang Gan, Shuang Luo* and Qiang Zhu*, A New Saddle-Shaped Aza Analog of Tetraphenylene: Atroposelective Synthesis and Application as a Chiral Acylating Reagent. CCS Chem. 2021, 3, 3427.
8.????? Fan Teng, Ting Yu, Yan Peng, Weiming Hu, Huaanzi Hu, Yimiao He, Shuang Luo* and Qiang Zhu*, Palladium-Catalyzed Atroposelective Coupling?Cyclization of 2-Isocyanobenzamides to Construct Axially Chiral 2-Aryl- and 2,3-Diarylquinazolinones. J. Am. Chem. Soc. 2021, 143, 2722.
9.????? Huaanzi Hu, Yan Peng, Ting Yu, Sidi Cheng, Shuang Luo* and Qiang Zhu*, Palladium-Catalyzed Enantioselective 7-exo-Trig Carbopalladation/Carbonylation: Cascade Reactions To Achieve Atropisomeric Dibenzo[b,d]azepin-6-ones. Org. Lett. 2021, 23, 3636.
10.?? Fan Teng, Yan Peng, Xilong Wang, Weiming Hu, Huaanzi Hu, Yimiao He, Shuang Luo* and Qiang Zhu*, Pd-Catalyzed Domino Imidoylation/Heck/C(sp2)–H Cyclization: Isocyanide Relay Strategy toward Tricyclic-Fused Heterocycles Containing an All-Carbon Quaternary Center. Org. Lett. 2020, 22, 8188.
11.?? Huaanzi Hu, Fan Teng, Jian Liu, Weiming Hu, Shuang Luo* and Qiang Zhu*, Enantioselective Synthesis of 2‐Oxindole Spirofused Lactones and Lactams by Heck/Carbonylative Cylization Sequences: Method Development and Applications. Angew. Chem. Int. Ed. 2019, 58, 9225.
12.?? Fan Teng, Weiming Hu, Huaanzi Hu, Shuang Luo* and Qiang Zhu*, Selective C?H or N?H Imidoylative Annulation of 2-(2-Isocyanophenyl)-1H-indoles Leading to Diverse Indole-fused Scaffolds. Adv. Synth. Catal. 2019, 361, 1414
13.?? Shuang Luo*, Zhuang Xiong, Yongzhi Lu and Qiang Zhu*, Enantioselective Synthesis of Planar Chiral Pyridoferrocenes via Palladium-Catalyzed Imidoylative Cyclization Reactions. Org. Lett. 2018, 20, 1837.
14.?? Zhuang Xiong, Jian Wang, Yanbo Wang, Shuang Luo* and Qiang Zhu*, Palladium-catalyzed C(sp2)–H aminoimidoylation of isocyano-containing arenes: synthesis of amino substituted N-heterocycles. Org. Chem. Front. 2017, 4, 1768
15.?? Zhuang Xiong, Dongdong Liang* and Shuang Luo*, Palladium-Catalyzed β-Selective C(sp2)?H Carboxamidation of Enamides by Isocyanide Insertion: Synthesis of N-Acyl Enamine Amides. Org. Chem. Front. 2017, 4, 1103.
16.?? Zeqiang Xie, Shuang Luo* and Qiang Zhu*, Pd-Catalyzed C(sp2)–H carbonylation of 2-benzylpyridines for the synthesis of pyridoisoquinolinones. Chem. Commun. 2016, 52, 12873.
17.?? Ziwei Hu, Shuang Luo* and Qiang Zhu*, Palladium-catalyzed intermolecular C-H amidation of indoles with sulfonyl azides. Sci. China. Chem. 2015, 58, 1349.
18.?? Shuang Luo, Fei-Xian Luo, Xi-Sha Zhang, Zhang-Jie Shi* Synthesis of dibenzopyranones through palladium-catalyzed directed C-H activation/carbonylation of 2-arylphenols. Angew. Chem. Int. Ed. 2013, 52, 10598.
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