主講人：陳可實 副研究員

　　時間：2019年10月18日 15：30 

　　地點：第一會議室A430

　　主持人：郭宜平 副研究員

Achievement introduction: Chromatin relaxation is required for generation of pluripotent stem cells, but how factor‐dependent chromatin opening is instructed remains poorly understood. Here, epigenetic profiling reveals Oct4 as a pioneer factor that loosens heterochromatin and cooperates with Klf4 and other chromatin remodellers during reprogramming.