????2013年本科畢業(yè)于西北農(nóng)林科技大學(xué)植物科學(xué)與技術(shù)專業(yè)。2013年至2018年就讀于復(fù)旦大學(xué)生命科學(xué)學(xué)院生物化學(xué)與分子生物學(xué)專業(yè)，導(dǎo)師為麻錦彪教授。2018年至2020年在南方科技大學(xué)從事博士后研究工作，合作導(dǎo)師為Dinshaw J. Patel以及黃鴻達(dá)教授。2020年入選中山大學(xué)“百人計(jì)劃”青年拔尖引進(jìn)人才，受聘于中山大學(xué)孫逸仙紀(jì)念醫(yī)院工作，任PI副研究員；2024年獲批廣東省“特支計(jì)劃”青年拔尖人才。2025年3月受聘于中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院，任創(chuàng)新藥物研究所核酸化學(xué)課題組長(zhǎng)，PI研究員。
????研究工作以（共同）第一/通訊作者發(fā)表在Nature Communications, Nucleic Acids Research, Molecular Plant, JBC, Journal of Virology, Frontiers in Microbiology, iScience, Structure等國(guó)際期刊。此外，以共同作者在Molecular Cell，PNAS，Cell research等發(fā)表多篇成果。目前擔(dān)任RICE, ACS Omega, Frontiers in Plant Science, BBA-Reviews on Cancer等期刊雜志的審稿人。個(gè)人主頁(yè)：https://www.x-mol.com/groups/wu_baixing. Google Scholar：https://scholar.google.com/citations?user=_bGMyZkAAAAJ&hl=ja.
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教育背景
2009.09-2013.09?? 西北農(nóng)林科技大學(xué)農(nóng)學(xué)院，植物科學(xué)與技術(shù)專業(yè)，學(xué)士
2013.09-2018.09?? 復(fù)旦大學(xué)生命科學(xué)學(xué)院，生物化學(xué)與分子生物學(xué)，博士
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工作經(jīng)歷
2018.06-2020.06?? 南方科技大學(xué)生物系，博士后
2020.06-2025.02?? 中山大學(xué)孫逸仙紀(jì)念醫(yī)院，PI，副研究員
2025.03-至今???? 中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院，醫(yī)藥創(chuàng)新研究所，PI，研究員
????本實(shí)驗(yàn)室聚焦于核酸生物學(xué)研究，采用多種生物化學(xué)、分子生物學(xué)、細(xì)胞生物學(xué)技術(shù)手段，利用X射線晶體學(xué)，冷凍電鏡（Cryo-EM），交聯(lián)質(zhì)譜，熒光標(biāo)記實(shí)時(shí)成像等。構(gòu)建多維度的核酸生物學(xué)功能研究體系，推動(dòng)基礎(chǔ)研究向臨床應(yīng)用轉(zhuǎn)化。主要研究方向包括：
1. RNA與DNA修飾相關(guān)蛋白的催化、識(shí)別、代謝機(jī)制研究；
2. 非編碼RNA生成相關(guān)蛋白的結(jié)構(gòu)與功能；
3. DNA復(fù)制與損傷修復(fù)相關(guān)蛋白的結(jié)構(gòu)生物學(xué)研究；
4. 環(huán)狀RNA疫苗研究；
5. 天然代謝產(chǎn)物生成的酶學(xué)機(jī)制研究。
[1] 國(guó)家自然科學(xué)基金；批準(zhǔn)年度：2018年；項(xiàng)目起止年月：2018-01至2021-12（已結(jié)題，參與）
[2] 中山大學(xué)“百人計(jì)劃”啟動(dòng)項(xiàng)目；批準(zhǔn)年度：2020年；項(xiàng)目起止年月：2020-06至2023-06（主持）
[3] 國(guó)家自然科學(xué)基金青年科學(xué)基金項(xiàng)目；批準(zhǔn)年度：2019年；項(xiàng)目起止年月：2020-01至2021-12（已結(jié)題，主持）
[4] 廣東省惡性腫瘤表觀遺傳與基因調(diào)控重點(diǎn)實(shí)驗(yàn)室開(kāi)放課題專項(xiàng)基金；批準(zhǔn)年度：2021年；項(xiàng)目起止年月：2021-02至2022-12 (已結(jié)題，主持)
[5] 中山大學(xué)青年教師培育項(xiàng)目（重點(diǎn)項(xiàng)目）；2023年；項(xiàng)目起止年月：2023-08至2023-12 (已結(jié)題，主持)
[6] 廣東省衛(wèi)健委“特支計(jì)劃”青年拔尖人才項(xiàng)目；2024年；項(xiàng)目起止年月：2024-10至2027-10 (在研，主持)
一作或通訊發(fā)表的文章 (* Corresponding, # First authors):
1)?Meng, C. #, Guo, W. #, Xiao, C. #, Wen, Y. #, Zhu, X., Zhang, Q., Liang, Y., Li, H., Xu, S., Qiu, Y. *, Chen, H. *, Lin, WJ. *, Wu, B.* (2025) Structural Basis for Psilocybin Biosynthesis. Nature Communications.
2)?Li, X. #, Guo W. #, Wen, Y. #, Meng, C., Zhang, Q., Chen, H., Zhao, X.*, Wu, B.* (2025) Molecular basis for the RNA binding properties of IGF2BP3 tandem RBDs. Structure. 2025 Feb 12: S0969-2126(25)00022-X.
3)?Wen, Y.#, Guo, W.#, Meng, C., Yang, J., Xu, S., Chen, H.*, Gan, J.*, Wu, B.*. Structural insights into the biosynthetic mechanism of Nα-GlyT and 5-NmdU hypermodifications of DNA. Nucleic Acids Research. 2024 Sep 12: gkae784.
4)?Guo, W.#, Wu, W.#, Wen, Y., Gao, Y., Zhuang, S., Meng, C., Chen, H., Zhao, Z.*, Hu, K.*, Wu, B.*. Structural insights into the catalytic mechanism of the AP endonuclease AtARP. Structure. 2024. 32, 1-15
5)?Guo, W.#; Li, X.#; Fan, J.#; Li, H.#; Wen, Y.; Meng, C.; Zhu, X.; Chen, H.; Zhang, Y.; Du, Y.*; Wu, B.*, Structural characterization of an isocytosine-specific deaminase VCZ reveals its application potential in the anti-cancer therapy. iScience. 2023, 26(9):107672
6)?Liu, D.; Dredge, B. K.; Bert, A.; Pillman, K.; Toubia, J.; Guo, W.; Dyakov, B. J.A.; Migault, M.; Conn, V. M.; Conn, S. J.; Gregory, P. A.; Gingras, A-C; Patel, D.; Wu, B.*; Goodall, G.*, ESRP1 controls biogenesis and function of a large abundant multiexon circRNA. Nucleic acids research. 2024 Feb 9;52(3):1387-1403.
7)?Li, X. #, Li, K. #, Guo, W., Wen, Y., Meng, C., Wu, B.*. (2022) Structure characterization of E. coli pseudouridine kinase PsuK. Frontiers in Microbiology. 2022; 13:926099.
8)?Wen Y.#, Li X.#, Guo W, Wu B*. Crystal structures of a new class of pyrimidine/purine nucleoside phosphorylase revealed a Cupin fold. Proteins. 2022; 90(6):1233-1241.
9)?Liu Y.#, Zhang L.#, Guo M., Chen L., Wu B*, Huang H.*. Structural basis for anti-CRISPR repression mediated by Aca1 and Aca2. 2021. Journal of Biological Chemistry. Dec;297(6):101357.
10)?Hou, Y.#, Sun J.#, Wu, B.#, Gao, Y.#, Nie H., Nie, Z., Quan, S., Wang Y.*, Cao, X*, Li, S.* (2021) CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis. Molecular Plant. 2021 Apr 5;14(4):688-699.
11)?Wang, N.#, Bao, H.#, Chen, L., Liu, Y., Li, Y., Wu, B.*, Huang H.* Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK. Nucleic acids research. 2019 Nov 4;47(19):10388-10399.
12)?Wu, B.#,*, Zhang, D.#, Nie, H.#, Shen, S., Li, Y., Li, S.* (2019) Structure of Arabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications for N6-methyl-AMP recognition and processing, RNA Biology, 16:10, 1504-1512
13)?Qiu, Q.#, Mei, H.#, Deng, X.#, He, K.#, Wu, B.#, Yao, Q., Zhang J., Lu, F., Ma, J.*, Cao, X.*(2019) DNA methylation repels targeting of Arabidopsis REF6. Nature Communications. (2019) 10:2063 ?
14)?Wu, B. #, Su, S. #, Deepak P. Patil, Liu, H., Gan, J., Samie R. Jaffrey, Ma, J.* (2018) Molecular Basis for The Specific and Multivariate Recognitions of RNA Substrates by Human hnRNPA2/B1. Nature Communications. 9(1):420.
15)?Wu, B., Li, L., Huang, Y*., Ma, J*., Min J*. (2017). Readers, writers and erasers of N6-methylated adenosine modification, Current Opinion in Structural Biology. 47:67-76.
16)?Li, W.#, Wu, B.#, Soca, WA., An, L.* (2018) Crystal Structure of Classical Swine Fever Virus NS5B Reveals a Novel N-terminal Domain. Journal of Virology. 92(14). pii: e00324-18.
17)?Wu, B. *, Xu, J., Su, S., Liu, H., Gan, J., Ma, J.* (2017) Structural insights into the specific recognition of DSR by the YTH domain-containing protein Mmi1. Biochemical and Biophysical Research Communications. 491(2):310-316.
18)?Li, Y.#, Wu, B.#, Liu, H., Gao, Y., Yang C., Chen X., Zhang, J., Chen, Y., Gu, Y., Li, J., Ma, J., Gan, J.* (2018) Structural insights into target DNA recognition by the double homeodomains of human DUX4. Biochemical and Biophysical Research Communications. 505(4):1161-1167
19)?Wu, B.#,*, Zhang, M.#, Su, S., Liu, H., Gan, J., Ma, J.* (2018) Structural insight into the role of VAL1 for targeting to FLC locus in Arabidopsis thaliana. Biochemical and Biophysical Research Communications. 501(2):415-422
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作為參與作者發(fā)表文章：
1)? Shen, Y.#, Liu, Y.#, Mao, S., Chen, R., Wang, M., Guo, M., Li, Y., Chen, W., Chen, F., Wu, B., Wang, C., Chen, W., Cui, H.*, Yuan, K.*, Huang, H*. Structural basis of the DEK-nucleosome complex and its implication on gene regulation. Nature Structural & Molecular Biology.
2)?Mao, Y.#, Zhang, J.#, Zhou, Q.#, He, X.#, Zheng, Z., Wei, Y., Zhou, K. Lin, Y., Yu, H., Zhang, H., Zhou, Y., Lin, P., Wu, B., Yuan, Y., Zhao, J., Xu, W.*, Zhao, S.*. (2024) Hypoxia Induces Mitochondrial Protein Lactylation to Limit Oxidative Phosphorylation. Cell Research. 2024. Jan;34(1):13-30.
3)?Yao, Q.#, Cao, G.#, Li, M., Wu, B, Zhang, X, Zhang, T., Guo, J., Yin, H, Shi, L., Chen, J, Yu, X., Zheng, L., Ma, J.*, Su, Y.*. (2018) Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice. Proc. Natl. Acad. Sci. U.S.A. 115(44):11250-11255.
4)?Su, S.#, Li, S.#, Deng, T.#, Gao, M., Yin, Y., Peng C., Wu, B., Liu, J., Ma, J.*, Zhang, K.* Structural insights into human m6A-METTL associated complex. Cell Research (2022) 0:1–13.
5)?Zhou, Q.#, Sun, WW. #, Chen, JC., Zhang, HL., Liu, J., Lin, Y., Lin PC., Wu, BX., An, YP., Huang L., Sun WX., Zhou, XW., Li, YM., Yuan, YY., Zhao, JY., Xu, W*., Zhao, SM.* Phenylalanine Impairs Insulin Signaling and Inhibits Glucose Uptake by Modifying IRβ. Nature Communications. 2022; 13(1):4291.
6)?Yang, Y. #, Wang, L.#, Han, X.#, Yang, W-L.#, Zhang, M.#, Ma, H-L., Sun, B-F., Li, A., Xia, J., Chen, J., Heng, J., Wu, B., Chen, Y-S., Xu, J-W., Yang, X., Yao, H., Sun, J., Lyu, C., Wang, H-L., Huang, Y, Sun, Y-P., Zhao, Y-L., Meng, A., Ma, J.*, Liu, F.*, Yang, Y-G.* (2019) RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Molecular Cell. 75, 1188–1202
7)?He, J. #, Ye, W.#, Choi, D.#, Wu, B., Zhai, Y., Guo, B., Duan, S., Wang, Y., Gan, J., Ma, W.*, Ma, J.* (2019) Structural analysis of Phytophthora suppressor of RNA silencing 2 (PSR2) reveals a conserved modular fold contributing to virulence. Proc. Natl. Acad. Sci. U.S.A. 16;116(16):8054-8059.
8)?Liu, H., Wang, R., Yu, X., Shen, F., Lan, W., Haruehanroengra, P., Yao, Q., Zhang, J., Chen, Y., Li, S., Wu, B., Zheng, L., Ma, J., Lin, J., Cao, C.*, Li, J.*, Sheng, J.*, Gan, J.*. (2018). High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads. Nucleic acids research. 46(21):11627-11638
9)?Liu, H.#, Yu, X.#, Chen, Y., Zhang, J., Wu, B., Zheng, L., Haruehanroengra, P., Wang, R., Li, S., Lin, J., Li, J., Sheng, J., Huang, Z. *, Ma, J. *, Gan, J. * (2017) Crystal structure of an RNA-cleaving DNAzyme. Nature Commnications. 8(1):2006
10)?Yu, J.#, He, Z.#, He, X. Luo, Z., Lian, L., Wu, B., Lan, P.* and Chen, H.* (2021) Comprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer. Frontiers in Oncology 2021 Nov 5; 11:771099. ?
11)?Liu, H., Shen, F., Haruehanroengra, P., Yao, Q., Cheng, Y., Chen, Y., Yang, C., Zhang, J., Wu, B., Luo, Q., Cui, R., Li, J., Ma, J. *, Sheng, J. *, and Gan, J. * (2017) A novel DNA structure containing AgI-mediated G:G and C:C Base Pairs. Angew. Chem. Int. Ed. 56(32):9430-9434.
12)?Liu, H., Cai, C., Haruehanroengra, P., Yao, Q., Chen, Y., Yang, C., Luo, Q., Wu, B., Li, J., Ma, J. *, Sheng, J. *, Gan, J*. (2017) Flexibility and stabilization of HgII-mediated C: T and T: T base pairs in DNA duplex. Nucleic acids research. 45(5):2910-2918.
13)?Zhang, J., Liu, H., Yao, Q., Yu, X., Chen, Y., Cui, R., Wu, B., Zheng, L., Zuo, J., Huang, Z*., Ma, J*., Gan, J*. (2016). Structural basis for single-stranded RNA recognition and cleavage by C3PO. Nucleic acids research. 44(19):9494-9504.
14)?Liu, Y., Chen, L., Wang, N., Wu, B., Bao, H.*, Huang, H.* Structural basis for histone H3 recognition by NASP in Arabidopsis. Journal of Integrative Plant Biology. 2022;
15）Liang, Q., Zhang X., Wei, Q., Wang, X., Zhang J., Sun, D., Fu X., Wu B., Nie, H., (2011) Establishment and Application of Multiplex PCR System Based on Molecular Markers for Glutenin Subunit Genes (Locus) in Wheat. Acta. Agron. Sin. 37(11):1942-1948
