康樂,中國科學(xué)院特聘研究員,中國科學(xué)院院士、發(fā)展中國家科學(xué)院院士,美國國家科學(xué)院等7個(gè)國家和國際組織的外籍院士,是國內(nèi)外著名生態(tài)基因組學(xué)專家。現(xiàn)任中科院北京生命科學(xué)院院長(zhǎng)、河北大學(xué)校長(zhǎng)。長(zhǎng)期從事生態(tài)基因組學(xué)研究,國家“973”項(xiàng)目首席科學(xué)家和基金委創(chuàng)新團(tuán)隊(duì)學(xué)術(shù)帶頭人,也是國際上幾個(gè)重要學(xué)術(shù)期刊的主編和編委。他將基因組學(xué)與生態(tài)學(xué)結(jié)合,系統(tǒng)研究動(dòng)物的適應(yīng)性和表觀可塑性。在相關(guān)領(lǐng)域發(fā)表SCI論文200余篇,重要論文發(fā)表在Nature, Science, Science Advances, Nature Communication, PNAS,Genome Biology等重要刊物上,總引用萬余次,是Elsevier選出的農(nóng)業(yè)和生物學(xué)高被引科學(xué)家(Scopus 2014-2021)。是F1000的Faculty member和Advisory board member。從1995年起,他已經(jīng)培養(yǎng)了90多名博士和碩士研究生,10多名博士后,許多人已經(jīng)成為國家重要的學(xué)術(shù)帶頭人,如特殊人才計(jì)劃入選者、研究員、教授、國家青年科技獎(jiǎng)和國家優(yōu)秀青年基金項(xiàng)目獲得者等。
主要開展生物過敏原引起的呼吸道過敏性疾病以及相關(guān)的免疫學(xué)機(jī)理研究。圍繞塵螨、蟑螂、花粉等過敏原造成的過敏性疾病發(fā)病機(jī)制的基礎(chǔ)研究,通過建立相關(guān)動(dòng)物模型及利用臨床樣本,在分子、細(xì)胞、基因組學(xué)水平上探索呼吸道過敏性疾病發(fā)生和發(fā)展的機(jī)制。開展綜合性和交叉型前沿研究,利用綜合性的平臺(tái)和多種技術(shù)手段,闡明其誘發(fā)的過敏疾病的發(fā)病機(jī)理,為過敏性疾病預(yù)防、診斷和治療性疫苗的研究奠定理論基礎(chǔ)。
1.國家自然科學(xué)基金委項(xiàng)目“作為昆蟲嗅覺進(jìn)化重要節(jié)點(diǎn)的飛蝗嗅覺編碼與處理機(jī)理研究”項(xiàng)目負(fù)責(zé)人;
2.國家自然科學(xué)基金委基礎(chǔ)科學(xué)中心項(xiàng)目“生物信息流的解碼與操控”項(xiàng)目骨干;
3.國家自然科學(xué)基金委面上項(xiàng)目“飛蝗嗅覺吸引行為的神經(jīng)分子機(jī)制”項(xiàng)目負(fù)責(zé)人;
4.中國科學(xué)院戰(zhàn)略性先導(dǎo)科技專項(xiàng)項(xiàng)目“生物互作機(jī)制的解構(gòu)與設(shè)計(jì)——農(nóng)業(yè)有害生物的智慧型防控”負(fù)責(zé)人。
2008年 國際昆蟲學(xué)會(huì) 執(zhí)行理事。
2019年 國際生物科學(xué)聯(lián)合會(huì)(IUBS)副主席。
2019年 國際生物科學(xué)聯(lián)合會(huì)中國委員會(huì)(CCIUBS)主席
2022年 國際科學(xué)理事會(huì)中國委員會(huì)(ISC-China)副主席
2011年 何梁何利生命科學(xué)與技術(shù)進(jìn)步獎(jiǎng)
2013年 美國昆蟲學(xué)會(huì)頒發(fā)的杰出科學(xué)家獎(jiǎng)
2015年 第八屆“談家楨生命科學(xué)獎(jiǎng)”成就獎(jiǎng)
2017年 國家自然科學(xué)二等獎(jiǎng)
2017年 中國科學(xué)院杰出成就獎(jiǎng)
2019年 馬世駿生態(tài)科學(xué)成就獎(jiǎng)
2021年 國際化學(xué)生態(tài)學(xué)會(huì)西弗斯坦-西蒙尼獎(jiǎng)
1.?????? Wang, Y., Zhang, Y., Lou, H., Wang, C., Ni, M., Yu, D., Zhang, L., & Kang, L. (2022). Hexamerin-2 Protein of Locust as a Novel Allergen in Occupational Allergy. Journal of Asthma and Allergy, 15, 145–155. doi.org/10.2147/JAA.S348825
2.?????? Guo, X., Yu, Q., Chen, D., Wei, J., Yang, P., Yu, J., Wang, X., & Kang, L. (2020). 4-Vinylanisole is an aggregation pheromone in locusts.?Nature,?584(7822), 584–588. doi.org/10.1038/s41586-020-2610-4
3.?????? Wang, Y., Tong, X., Yuan, S., Yang, P., Li, L., Zhao, Y., & Kang, L. (2022). Variation of TNF modulates cellular immunity of gregarious and solitary locusts against fungal pathogen?Metarhizium anisopliae.?Proc. Nat. Acad. Sci. (USA),?119(6), e2120835119.? doi.org/10.1073/pnas.2120835119
4.?????? Wang, H., Jiang, F., Liu, X., Liu, Q., Fu, Y., Li, R., Hou, L., Zhang, J., He, J., & Kang, L. (2022). Piwi/piRNAs control food intake by promoting neuropeptide F expression in locusts. EMBO Reports,?23(3), e50851. doi.org/10.15252/embr.202050851
5.?????? He, J., Zhu, Y.N., Wang, B., Yang, P., Guo, W., Liang, B., Jiang, F., Wang, H., Wei, Y., and Kang, L. (2022). piRNA-guided intron removal from pre-mRNAs regulates density-dependent reproductive strategy. Cell Report, 39, 110593.
6.?????? Du, B., Ding, D., Ma, C., Guo, W., & Kang, L. (2022). Locust density shapes energy metabolism and oxidative stress resulting in divergence of flight traits.?Proc. Nat. Acad. Sci. (USA),?119(1), e2115753118. doi.org/10.1073/pnas.2115753118
7.?????? Wei, J., Shao, W., Cao, M., Ge, J., Yang, P., Chen, L., Wang, X., & Kang, L. (2019). Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor.?Science Advances,?5(1), eaav5495. doi.org/10.1126/sciadv.aav5495
8.?????? Yang, M., Wang, Y., Liu, Q., Liu, Z., Jiang, F., Wang, H., Guo, X., Zhang, J., & Kang, L. (2019). A β-carotene-binding protein carrying a red pigment regulates body-color transition between green and black in locusts.?eLife,?8, e41362. doi.org/10.7554/eLife.41362
9.?????? Guo, X., Ma, Z., Du, B., Li, T., Li, W., Xu, L., He, J., & Kang, L. (2018). Dop1 enhances conspecific olfactory attraction by inhibiting miR-9a maturation in locusts.?Nature Comm.,?9(1), 1193. doi.org/10.1038/s41467-018-03437-z.
10.??? Ding, D., Liu, G., Hou, L., Gui, W., Chen, B., & Kang, L. (2018). Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts.?Nature Comm.,?9(1), 4991. doi.org/10.1038/s41467-018-07529-8
11.??? Chen, B., Zhang, B., Xu, L., Li, Q., Jiang, F., Yang, P., Xu, Y., & Kang, L. (2017). Transposable Element-Mediated Balancing Selection at Hsp90 Underlies Embryo Developmental Variation.?Molecular Biology and Evolution,?34(5), 1127–1139. doi.org/10.1093/molbev/msx062
12.??? He, J., Chen, Q., Wei, Y., Jiang, F., Yang, M., Hao, S., Guo, X., Chen, D., & Kang, L. (2016). MicroRNA-276 promotes egg-hatching synchrony by up-regulating brm in locusts.?Proc. Nat. Acad. Sci. (USA),?113(3), 584–589. doi.org/10.1073/pnas.1521098113
13.??? Yang, M., Wang, Y., Jiang, F., Song, T., Wang, H., Liu, Q., Zhang, J., Zhang, J., & Kang, L. (2016). miR-71 and miR-263 Jointly Regulate Target Genes Chitin synthase and Chitinase to Control Locust Molting.?PLoS Genetics,?12(8), e1006257. doi.org/10.1371/journal.pgen.1006257
14.??? Wang, X., & Kang, L. (2014). Molecular mechanisms of phase change in locusts.?Annual Review of Entomology,?59, 225–244. doi.org/10.1146/annurev-ento-011613-162019
15.??? Wang, X., Fang, X., Yang, P., Jiang, X., Jiang, F., Zhao, D., Li, B., Cui, F., Wei, J., Ma, C., Wang, Y., He, J., Luo, Y., Wang, Z., Guo, X., Guo, W., Wang, X., Zhang, Y., Yang, M., Hao, S., … Kang, L. (2014). The locust genome provides insight into swarm formation and long-distance flight.?Nature Comm.,?5, 2957. doi.org/10.1038/ncomms3957
16.??? Yang, M., Wei, Y., Jiang, F., Wang, Y., Guo, X., He, J., & Kang, L. (2014). MicroRNA-133 inhibits behavioral aggregation by controlling dopamine synthesis in locusts.?PLoS Genetics,?10(2), e1004206. doi.org/10.1371/journal.pgen.1004206
17.??? Wang, Y., Yang, P., Cui, F., & Kang, L. (2013). Altered immunity in crowded locust reduced fungal (Metarhizium anisopliae) pathogenesis.?PLoS Pathogens,?9(1), e1003102. https://doi.org/10.1371/journal.ppat.1003102
18.??? Cease, A. J., Elser, J. J., Ford, C. F., Hao, S., Kang, L., & Harrison, J. F. (2012). Heavy livestock grazing promotes locust outbreaks by lowering plant nitrogen content.?Science,?335(6067), 467–469. doi.org/10.1126/science.1214433
19.??? Wu, R., Wu, Z., Wang, X., Yang, P., Yu, D., Zhao, C., Xu, G., & Kang, L. (2012). Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts.?Proc. Nat. Acad. Sci. (USA),?109(9), 3259–3263. doi.org/10.1073/pnas.1119155109
20.??? Ma, Z., Guo, W., Guo, X., Wang, X., & Kang, L. (2011). Modulation of behavioral phase changes of the migratory locust by the catecholamine metabolic pathway.?Proc. Nat. Acad. Sci. (USA),?108(10), 3882–3887. doi.org/10.1073/pnas.1015098108
21.??? Guo, W., Wang, X., Ma, Z., Xue, L., Han, J., Yu, D., & Kang, L. (2011). CSP and takeout genes modulate the switch between attraction and repulsion during behavioral phase change in the migratory locust.?PLoS Genetics,?7(2), e1001291. doi.org/10.1371/journal.pgen.1001291
22.??? Wei, J., Wang, L., Zhao, J., Li, C., Ge, F., & Kang, L. (2011). Ecological trade-offs between jasmonic acid-dependent direct and indirect plant defences in tritrophic interactions.?New Phytologist,?189(2), 557–567. doi.org/10.1111/j.1469-8137.2010.03491.x
23.??? Zhang, Y., Wang, X., & Kang, L. (2011). A k-mer scheme to predict piRNAs and characterize locust piRNAs.?Bioinformatics,?27(6), 771–776. doi.org/10.1093/bioinformatics/btr016
24.??? Wei, Y., Chen, S., Yang, P., Ma, Z., & Kang, L. (2009). Characterization and comparative profiling of the small RNA transcriptomes in two phases of locust.?Genome Biology,?10(1), R6. doi.org/10.1186/gb-2009-10-1-r6
25.??? Kang, L., Chen, X., Zhou, Y., Liu, B., Zheng, W., Li, R., Wang, J., & Yu, J. (2004). The analysis of large-scale gene expression correlated to the phase changes of the migratory locust.?Proc. Nat. Acad. Sci. (USA),?101(51), 17611–17615. doi.org/10.1073/pnas.0407753101