中國科學技術大學學士、康奈爾大學博士，中盛溯源生物科技有限公司聯合創(chuàng)始人、首席技術官（CTO）。主要研究內容：利用重編程、定向分化、和基因修飾等技術。開發(fā)hiPSC來源細胞藥物開發(fā)，參與承接科技部十三五和十四五國家重點研發(fā)計劃《干細胞制劑及應用的標準化研究》和《干細胞及相關產品質量控制及評價技術》，建立中國人群“超級供體”hiPSC庫、參與起草國內首個《人誘導多能干細胞》標準、完成臨床級hiPSC建庫質量復核。2022年9月首個iPSC來源間充質樣細胞治療產品“NCR100注射液”獲得國家藥品監(jiān)督管理局藥品審評中心的臨床試驗默示許可。
1． hiPSC向體節(jié)中胚層細胞分化，開發(fā)iMSC等細胞治療產品；
2． hiPSC向血液譜系分化，開發(fā)iNK等腫瘤免疫治療產品；
3． hiPSC向特定神經祖細胞分化，開發(fā)面向帕金森等神經退行性疾病的細胞治療產品。
發(fā)表論文和專利
1. Zhang H, Su B, Jiao L, Xu ZH, Zhang CJ, Nie J, Gao ML, Zhang YV#, Jin ZB#. Transplantation of GMP-grade human iPSC-derived retinal pigment epithelial cells in rodent model: the first pre-clinical study for safety and efficacy in China. Ann Transl Med. 2021 Feb;9(3):245. (#Corresponding)
2. Yu J, Zhao T, Ma A, Zhang Y, Zhang K, Cheng L, Deng H, Kang J, Jin Z, Pan G, Hao J, Zhang Y, Fu B, Hu S, Na J, Liu Y, Cao J, Wang L, Zhu H. 《人誘導多能干細胞團體標準》，中國細胞生物學會，2021 Jan.
3. 一種中腦多巴胺能神經前體細胞及其制備方法和應用, 專利申請?zhí)?01910169525.0
4. 視網膜色素上皮細胞及其制備方法和應用，專利申請?zhí)?01910320076.5.
5. 一種腎上皮細胞及其制備方法和應用，專利申請?zhí)?01910834502.7.
6. 一種間充質干細胞及其制備方法和應用，專利號ZL201910884482.4.
7. 一種微環(huán)游離型載體高效重編程血液細胞生成iPSC的方法, 專利號ZL201810252408.6
8. 一種通過蠑螈Oct4將人類血液細胞重編程為iPSC的方法, 專利號ZL201810137319.7 9. Wang AB, Zhang YV, and Tumbar T. (2017) Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation. EMBO J. 2017 Jan 4;36(1):61-78.
10. Lee J, Kang S, Lilja K, Colletier K, Scheitz C, Zhang YV, and Tumbar T. (2016) Signaling couples hair follicle stem cell quiescence with reduced H3K4/K9/K27me3 levels for proper tissue homeostasis. Nature Communications 2016 Apr 15;7:11278
11. Zhang YV, Johns L., Yu J. (2014) Generation of keratinocytes from pluripotent stem cells and maintenance of keratinocyte cultures. US Patent CDIN.P0055US.P1.
12. Zhang YV, White B.S., Shalloway D.I., Tumbar T. (2010) Stem cell dynamics in mouse hair follicles: a story from cell division counting and single cell lineage tracing. Cell Cycle 2010 Apr 19;9(8).
13. Zhang YV, Cheong J., Ciapurin N., McDermitt D.J., Tumbar T. (2009) Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells. Cell Stem Cell, Volume 5, Issue 3, 267-278.
14. Waghmare S.K., Bansal R., Lee J.*, Zhang YV*, McDermitt D.J., Tumbar T. (2008) Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells. EMBO J. 27(9):1309-20. (* equal contribution)
15. Osorio, K.M., Lee, S.E., McDermitt, D.J., Waghmare, S.K., Zhang, YV, Woo, H.N. Tumbar, T. (2008) Acute Myeloid Leukemia Factor 1 Controls Developmental but not Injury Driven Activation of Hair Follicle Stem Cells. Development, 135, 1059-1068.
16. Yao X., Zhang Y., Chen W., Dou Z. (2005) Patent: A new developed absorbent polymer for protein condensation. The State Intellectual Property Office of the People's Republic of China Patent No.: ZL200310106547.1
17. Dou Z., Ding X., Zereshki A., Zhang Y., Zhang J., Wang F., Sun J., Huang H., Yao X. (2004) TTK kinase is essential for the centrosomal localization of TACC2. FEBS Lett, 572: 51–56.
