熊曉犁，博士，研究員，英國微生物學(xué)會(huì)會(huì)員。在英國布里斯托大學(xué)生物化學(xué)系/細(xì)胞和分子醫(yī)學(xué)系分別獲得生物化學(xué)與生物技術(shù)學(xué)士學(xué)位和病理學(xué)與微生物學(xué)博士學(xué)位。熊曉犁研究員先后在英國MRC National Institute for Medical Research (現(xiàn)Francis Crick Institute) 病毒學(xué)系 Sir John Skehel研究組，美國華盛頓大學(xué)（西雅圖）生物化學(xué)系，英國MRC Laboratory of Molecular Biology結(jié)構(gòu)生物學(xué)系從事病原微生物致病機(jī)理的研究。2020年9月加入中國科學(xué)院廣州生物醫(yī)藥與健康研究院。
?
近10年來熊曉犁研究員研究了H5N1, H7N9, H10N8流感病毒的跨種傳播機(jī)理（Xiong et. al. Nature 2013a, Xiong et. al. Nature 2013b, Xiong et. al. Virology 2014, Vachieri*, Xiong.* et. al. ?Nature 2014）, 流感病毒的裝配機(jī)制 （Peukes*, Xiong*# et. al. Nature 2020）。冠狀病毒的入侵機(jī)制 (Xiong et. al. J. Virology 2018, Walls*, Xiong* et. al. Cell 2019), 新型冠狀病毒表面抗原S蛋白的穩(wěn)定化（Xiong*# et. al. ?Nat. Struct. Mol. Biol. 2020）等科學(xué)問題。研究團(tuán)隊(duì)旨在運(yùn)用結(jié)構(gòu)生物學(xué)與生物化學(xué)方法探明病原微生物的致病機(jī)理，并在理解其致病機(jī)理的基礎(chǔ)上開發(fā)干預(yù)手段。
1.????? Xiong, X.*#, Qu, K.*, Ciazynska, K.A., Hosmillo, M., Carter, A.P., Ebrahimi, S., Ke, Z., Scheres, S.H.W., Bergamaschi, L., Grice, G.L., Zhang, Y., The CITIID-NIHR COVID-19 Bioresource, Nathan, J.A., Baker, S., James, L.C., Helen, E., Goodfellow, I., Doffinger, R., and Briggs, J.A.G. # (2020). A thermostable, closed, SARS-CoV-2 spike protein trimer. Nat. Struct. Mol. Biol.
?
2.????? Peukes, J.*, Xiong, X.*#, Erlendsson, S., Qu, K., Wan, W., Leslie, J., Schraidt, O., Kummer, S., Freund, S.M.V., Kraeusslich H-G., Briggs, J.A.G #. (2020). The native structure of the assembled matrix protein 1 of influenza A virus. Nature.
?
3.????? Zunlong Ke, Oton, J., Qu, K., Cortese, M., Zila, V., McKeane, L., Nakane, T., Zivanov, J., Neufeldt2, C.J., Lu, J.M., Peukes, J., Xiong, X., Kraeusslich, H-G., Scheres, S.H.W., Bartenschlager, R., Briggs, J.A.G. (2020). Structures, conformations and distributions of SARS-CoV-2 spike protein trimers on intact virions. Nature.
?
4.????? Mlcochova, P., Collier, D., Ritchie, A. V, Assennato, S.M., Hosmillo, M., Goel, N., Meng, B., Chatterji, K., Mendoza, V., Temperton, N., Kiss, L., Ciazyns, K.A., Xiong, X., Briggs, J.A.G., Nathan, J., Mescia, F., Zhang, H., Barmpounakis, P., Demeris, N., et al. (2020). Combined point of care SARS-CoV-2 nucleic acid and antibody testing in suspected moderate to severe COVID-19 disease. Cell Reports Medicine.
?
5.????? Zheng, A., Sun, W., Xiong, X., Freyn, A.W., Peukes, J., Stromeier, S., Nachbagauer, R., Briggs, J.A.G., Krammer, F., and Palese, P. (2020). Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals. J. Virol. .
?
6.????? Gamblin, S.J., Vachieri, S.G., Xiong, X., Zhang, J., Martin, S.R., and Skehel, J.J. (2020). Hemagglutinin Structure and Activities. Cold Spring Harb. Perspect. Med. a038638.
?
7.????? Walls, A. C.*, Xiong, X.*, Park, Y, Tortorici, M.A., Snijder, J., Quispe, J., Cameroni, E., Dai, M., Zambon, M., Rey, F. A., Corti, D., Veesler, D. (2019). Unexpected receptor functional mimicry elucidates activation of coronavirus fusion. Cell 176,1026-1039
?
8.????? Xiong, X.,Tortorici, M. A., Snijder, J., Yoshioka, C., Walls, A. C., Li, W., McGuire, A. T., Rey, F. A., Bosch, B., Veesler, D., (2018) Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections. J. Virology, 92, e01628-17
?
9.????? Walls, A. C, Tortorici, M. A, Snijder, J, Xiong, X, Bosch, B. J, Rey, F. A and Veesler, D., (2017) Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion. Proc Natl Acad Sci. U S A 114:11157-11162.
?
10.?? Xiong, X., Corti, D., Liu, J., Pinna, D., Foglierini, M., Calder, L.J., Martin, S. R., Lin, Y.P., Walker, P. A., Collins, P. J., Moine, I., Suguitan Jr., A.L., Santos, C., Temperton, N.J., Subbarao, K., Lanzavecchia, A., Gamblin, S.J., Skehel, J. J., (2015) Structures of complexes formed by H5 influenza haemagglutinin with a potent broadly neutralizing human monoclonal antibody. Proc Natl Acad Sci U S A 112, 9430-9435.
?
11.?? Xiong, X. McCauley, J.W., Steinhauer, D.A. (2014). Receptor Binding Properties of the Influenza Virus Hemagglutinin as a Determinant of Host Range. Curr Top Microbiol Immunol 385, 63-91
?
12.?? Vachieri, S.G.*, Xiong, X.*, Collins, P.J., Walker, P.A., Martin, S.R., Haire, L.F., Zhang, Y., McCauley, J.W., Gamblin, S.J., and Skehel, J.J. (2014). Receptor binding by H10 influenza viruses. Nature 511, 475-477.
?
13.?? Xiong, X.*, Xiao, H.*, Martin, S. R., Coombs, P. J., Liu, J., Collins, P. J., Vachieri, S. G., Walker, P. A., Lin, Y. P., McCauley, J. W., Gamblin, S. J. & Skehel, J. J. (2014). Enhanced human receptor binding by H5 haemagglutinins. Virology, 456-457, 179-187.
?
14.?? Xiong, X., Tuzikov, A., Coombs, P. J., Martin, S., Walker, P. A., Gamblin, S. J., Bovin, N. & Skehel, J. J. (2013). Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus. Virus Res, 178, 12-4.
?
15.?? Xiong, X., Martin, S. R., Haire, L. F., Wharton, S. A., Daniels, R. S., Bennett, M. S., McCauley, J. W., Collins, P. J., Walker, P. A., Skehel, J. J. & Gamblin, S. J. (2013). Receptor binding by an H7N9 influenza virus from humans. Nature, 499, 496-9.
?
16.?? Xiong, X.*, Coombs, P. J.*, Martin, S. R.*, Liu, J., Xiao, H., McCauley, J. W., Locher, K., Walker, P. A., Collins, P. J., Kawaoka, Y., Skehel, J. J. & Gamblin, S. J. (2013). Receptor binding by a ferret-transmissible H5 avian influenza virus. Nature, 497, 392-6.
?
?
18.?? Xiong, X., Bromley, E. H., Oelschlaeger, P., Woolfson, D. N. & Spencer, J. (2011). Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a gram-negative bacterium. Nucleic Acids Res, 39, 3917-27.
?
l?共同第一作者。#共同通訊作者。
?
?
?
?
