2002年-2006年：清華大學生物科學與技術系，博士

1998年-2002年：山東大學生命科學學院，學士

2007年-2010年: Thomas Jefferson University, 博士后

2010年－至今： 中國科學院廣州生物醫(yī)藥與健康研究院 研究員

·國家自然科學“杰出青年“基金?

·國家重點研發(fā)計劃首席科學家

·廣東省科學技術獎自然科學一等獎（第一完成人）

·樹蘭醫(yī)學青年獎

·丁穎科技獎

·國家自然科學優(yōu)秀青年基金

·2016年干細胞青年研究員獎

·廣東省自然科學杰出青年基金獲得者（首屆）

·國際生物物理學會"2011?Young?Bioenergeticist?award"

·中國科學院廣州教育基地優(yōu)秀研究生導師

·中國科學院廣州分院優(yōu)秀青年科學家

1. Hu,Z.,Yang,L.,Zhang,M.,…Liu,X*. (2024).?A?novel protein?CYTB-187AA?encoded by the mitochondrial?gene CYTB modulates mammalian early development Cell Metabolism,36(7):1586-1597.e7.?(Cell Metabolism當期專文評述)
2. Ying,Z.,Xiang G.,Zheng,L.,…Liu,X*. (2018).?Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming. Cell Metabolism,28(6):935-945.
3. Ying,Z.,Chen K.,Zheng,L.,…Liu,X*. (2016).?Transient activation of mitoflashes modulates Nanog at the early phase of somatic cell reprogramming. Cell Metabolism,23(1):220-226.
4. Li,L.,Chen,K.,Wang,T.,…Liu,X*. (2020). Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism?2(9):882-892.
5. Long,Q.,Zhou,Y.,Wu,H.,…Liu,X*. (2021). Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation.?Nature Structural & Molecular Biology 28(11):900-908.
6. Li,W.,Long,Q.,Wu,H.,…Liu,X*. (2022). Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation. Nature Communications,?13(1):7414. (Editors’Highlights)
7. Yang,L.,Ruan,Z.,Lin,X.,…Liu,X*. (2024). NAD⁺?dependent UPR^mt?activation underlies intestinal aging caused by mitochondrial DNA mutations Nature Communications,?15: 546?
8. Bao,F.,Zhou,L.,Zhou,R.,…Tian,M*&Liu,X*. (2022). Mitolysosome exocytosis,a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances,8(15):eabk2376.
9. Wu,Y.,Chen,K.,Xing,G.,…Liu,X*. (2019). Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition. Science Advances,5(11):eaax7525.
10. Guo,J.,Duan,L.,He,X.,…Liu,X*. (2021). A combined model of human iPSC-derived liver organoids and hepatocytes reveals ferroptosis in DGUOK mutant mtDNA depletion syndrome. Advanced?Science?8(10):2004680. (封面)
11. Li,S.,Guo,J.,Ying,Z.,...Liu,X*. (2015). Valproic acid‐induced hepatotoxicity in Alpers syndrome is associated with mitochondrial permeability transition pore opening‐dependent apoptotic sensitivity in an induced pluripotent stem cell model.?Hepatology,?61(5):1730-1739.
12. Chen,K.,Long,Q.,Xing,G.,…Pei,D*& Liu,X*. (2020). Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO Journal,39(1):e99165 (F1000推薦)
13. Liao,R.,Wu,Y.,Le,Q.,… Liu,X*?& Li,P*. (2023). BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells. EMBO Journal,2023 Nov 2;42(21):e113448.
14. Xiang,G.,Yang,L.,Long,Q.,…Liu,X*. (2017). BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming. Autophagy,13(9):1543-1555.
15. Zhou,Y.,Long,Q.,Wu,H.,…Liu,X*. (2020). Topology-dependent,bifurcated mitochondrial quality control under starvation. Autophagy,16(3):562-574. (封面)
16. Wu,?Y.,Chen,?K.,Li L.,…Liu,X*. (2022). Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation.?Cell Death & Differentiation,?29(11):2316-2331.
17. Xing,?G.,Liu,?Z.,Huang?L.,…Pei,D*?Liu,X*?& Chen,K*. (2022). MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening.?Cell Death & Differentiation,?29(5):1042-1054.
18. Yao,D.,Li,Y.,Zeng,S.,…Liu,X*. (2022).?Short-form OPA1 is a molecular chaperon in mitochondrial intermembrane space. Science China-Life Sciences,?65(2):227-235.?(封面).
19. Wang,R.,Bao,F.,Lu,M.,…Zhang,Q.*,Liu,X*. (2024). MSC-mediated mitochondrial transfer restores mitochondrial DNA?and function in neural progenitor cells of Leber's Hereditary Optic Neuropathy.?Science China-Life Sciences,?Jul 24,2024??https://doi.org/10.1007/s11427-024-2647-8
20. Yang,L.,Lin,X.,Tang,H.,....Liu,X*. (2020). ?Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD⁺?redox. Aging Cell?19(9):e13206.
21. Bao,F.,Shi,H.,Gao,M.,…Liu,X*.?(2018). Polybrene induces neural degeneration by bidirectional Ca²⁺?influx dependent mitochondrial and ER-mitochondrial dynamics.?Cell Death & Disease,9(10):966.
22. Li,L.,Chen,K.,Wu Y.,...Liu,X*. (2017). Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction. Cell Death & Disease,8(10):e3107.
23. Lin,Y.,Xiao,M.,Chen,H.,Meng,Y.,Zhao,N.,Yang,L.,Tang,H.,Wang,J.,Liu,X*,Zhu,Y.*,Zhuang,S.*. (2019). A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation. Cell Death & Disease,10(7):528
24. Yang,L.,Long,Q.,Liu,J.,...Liu,X*.?(2015). Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA.?Cellular and Molecular Life Sciences,?72(13):2585-2598.?
25. Chen,K.,Long,Q.,Wang,T.,… Liu,X*?&?Pei,D*. (2016). Gadd45a is a heterochromatin relaxer that enhances iPS cell?generation. EMBO Reports,17(11):1641-1656.
26. Bao,F.,Shi,H.,Long,Q.,…Liu,X*. (2016). Mitochondrial membrane potential-dependent endoplasmic reticulum fragmentation is an important step in neuritic degeneration.?CNS Neuroscience & Therapeutics,?22(8):648-660. ?(封面)
27. Yang,L.,Tang,H.,Lin,X....Liu,X*. (2020). OPA1-Exon4b binds to mtDNA D-loop for transcriptional and metabolic modulation,independent of mitochondrial fusion. Frontiers in Cell and Developmental Biology,?8: 180.
28. Wu,Y.,Chen,K.,Liu,X.,...Liu,X*.?(2015). Srebp‐1 Interacts with c‐Myc to Enhance Somatic Cell Reprogramming.?Stem Cells,?34(1):83-92.
29. Long,Q.,Zhao,D.,Fan,W.,...Wang X*?& Liu,X*.?(2015). Modeling of mitochondrial donut formation.?Biophysical Journal,?109(5):892-899.
30. Liu,W.,Long,Q.,Chen,K.,...& Liu,X*. (2013). Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation.?Biochemical and Biophysical Research Communications,?431(4),767-771.
31. Wu,Y.,Liu,Y.,Hao,Z.,Liu,X*. (2022). NAD+ is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1. Life Medicine,1(3),401-405. (Most Picked Paper Award)
32. Tang,H.,Hu,Z.,Yang,L.,...& Liu,X*. (2022). OPA1-Exon4b modulates?the migration and invasion of hepatocellular carcinoma?cells?by ATP regulation. Mitochondrial Communications,?1,16-22
33. Qi,J.,Long,Q.,Yuan Y.,…& Liu,X*. (2023). Mitochondrial DNA?mutation affects the pluripotency of embryonic stem cells through modulating metabolism,Genome Instability & Disease,4(1),?12–20.
34. Liu,X.,?Weaver,D.,Shirihai,O.,& Hajnóczky,G. (2009). Mitochondrial ‘kiss‐and‐run’:interplay between mitochondrial motility and fusion–fission dynamics. The EMBO Journal,?28(20),3074-3089. (F1000推薦)
35. Liu,X.,& Hajnoczky,G. (2011). Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress. Cell Death & Differentiation,?18(10),1561-1572.?(F1000推薦)
36. Weaver,D.,Eisner,V.,?Liu,X.,…?& Hajnóczky,G. (2014). Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion.?Molecular Cell,?54(5),870-878.?(co-first author)