2021-至今?中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院 副研究員

2018 -2020 中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院 博士后

2015- 2018 廣州醫(yī)科大學(xué)/呼吸疾病國(guó)家重點(diǎn)實(shí)驗(yàn)室 博士

2011-2015 中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院 研究實(shí)習(xí)員/助理研究員

2008-2011 沈陽(yáng)藥科大學(xué)/軍事醫(yī)學(xué)科學(xué)院生物工程研究所 碩士

2004-2008 山東第一醫(yī)科大學(xué) 學(xué)士

病毒疫苗與免疫

1. 國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目，92269201，2023-2026，合作方負(fù)責(zé)人

2. 國(guó)家自然科學(xué)基金面上項(xiàng)目，32370171，2024-2027，負(fù)責(zé)人

3. 國(guó)家自然科學(xué)基金青年項(xiàng)目，32000124，2021-2023，負(fù)責(zé)人

4. 中國(guó)博士后特別資助項(xiàng)目，2020T130115ZX，2018-2020，負(fù)責(zé)人

5. 中國(guó)博士后基金面上項(xiàng)目，2019M663140，2018-2020，負(fù)責(zé)人

6. 廣東省自然科學(xué)基金面上項(xiàng)目，2021A1515010456， 2021-2023，負(fù)責(zé)人

7. 廣東省科技攻關(guān)應(yīng)急專項(xiàng)，2020B111109004， 2020-2021，子課題負(fù)責(zé)人

8. 中國(guó)科學(xué)院青促會(huì)項(xiàng)目，2022361，2022-2025，負(fù)責(zé)人

代表論著：^#共同第一作者，*通訊作者

1. Chen S^#, Zhang Z^#, Wang Q^#, Yang Q^#, Yin L, Ning L, Chen Z, Tang J, Deng W, He P, Li H, Shi L, Deng Y, Liu Z, Bu H, Zhu Y, Liu W, Qu L, Feng L, Xiong X, Sun B, Zhong N, Li F, Li P^*, Chen X^*, Chen L^*. 2024. Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies. Signal Transduct Target Ther 9:190.
2. Li H^#, Yang C^#, Yin L, Liu W, Zhang Z, Liu B, Sun X, Liu W, Lin Z, Liu Z, He P, Feng Y, Wang C, Wang W, Guan S^*, Wang Q^*, Chen L^*,?Li P^*. 2024. Comparative immunogenicity of monovalent and bivalent adenovirus vaccines carrying spikes of early and late SARS-CoV-2 variants. Emerg Microbes Infect.
3. Wen Z^#,?Li P^#, Yuan Y^#,?Wang C^#,?Li M,?Wang H,?Shi M,?He Y,?Cui M,?Chen L^*, Sun C^*.?2024. Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques. eLife.?DOI: 10.7554/eLife.95964
4. Wang Q^#, Yang C^#, Yin L^#, Sun J^#, Wang W^#, Li H, Zhang Z, Chen S, Liu B, Liu Z, Shi L, Liu X, Guan S, Wang C, Qu L, Feng Y, Niu X, Feng L, Zhao J^*, Li P^*, Chen L^*, Zhong N. 2023. Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants. Signal Transduct Target Ther?8:167.
5. Li P^#*,?Wang Q^#, He Y^#, Yang C^#, Zhang Z, Liu Z, Liu B, Yin L, Cui Y, Hu P, Liu Y, Zheng P, Wang W, Qu L, Sun C, Guan S, Feng L^*, Chen L^*. 2023. Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques. Emerg Microbes Infect?12:e2136538.
6. Jie F^#, Wu X^#, Zhang F^#, Li J^#, Liu Z, He Y, Li C, Zhang H, Lin Y, Zhu X, Yu H, Liu Y, Li Z, Qu L^*, Chen L^*, Li P^*. 2023. Influenza Virus Infection Increases Host Susceptibility To Secondary Infection with Pseudomonas aeruginosa, and This Is Attributed To Neutrophil Dysfunction through Reduced Myeloperoxidase Activity. Microbiol Spectr?11:e0365522.
7. He Y^#, Wu C^#, Liu Z^#, Zhang Y, Feng F, Lin Z, Wang C, Yang Q, Wen Z, Liu Y, Zhang F, Lin Y, Zhang H, Qu L, Li L, Cai W, Sun C^*, Chen L^*, Li P^*. 2023. Arsenic trioxide-induced apoptosis contributes to suppression of viral reservoir in SIV-infected rhesus macaques. Microbiol Spectr?11:e0052523.
8. Liu W^#, Li H^#, Liu B^#, Lv T^#, Yang C, Chen S, Feng L, Lai L, Duan Z, Chen X,?Li P^*,?Guan S^*, Chen L^*. 2023. A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine. Emerg Microbes Infect?12:2233643.
9. Yu P^#, Liu Z^#, Zhu Z^#, Yang J^#, Deng M^#, Chen M, Lai C, Kong W, Xiong S, Wan L, Mai W, Chen L, Lei Y, Khan SA, Ruan J, Kang A, Guo X, Zhou Q, Li W, Chen Z^*, Liang Y^*, Li P^*, Zhang L^*, Ji T^*. 2023. Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees. Virol Sin?38:233-243.
10. Zhang L^#, Yang J^#, Lai C^#, Wan L^#, Xiong S^#, Kong W^#, Liu Z, Yu P, Chen M, Mai W, Khan SA, Deng M, Chen L, Lei Y, Zhou Q, Yu N^*, Li P^*, Chen Z^*, Ji T^*. 2023. Immunity against Delta and Omicron variants elicited by homologous inactivated vaccine booster in kidney transplant recipients. Front Immunol 13:1042784.
11. Wang H^#, Li P^#, Zhang M, Bi J, He Y, Li F, Yu R, Gao F, Kong W, Yu B^*, Chen L^*, Yu X^*. 2022. Vaccine with bacterium-like particles displaying HIV-1 gp120 trimer elicits specific mucosal responses and neutralizing antibodies in rhesus macaques. Microb Biotechnol?15:2022-2039
12. Wu C^#, He Y^#, Zhao J^#, Luo K, Wen Z, Zhang Y, Li M, Cui Y, Liu Z, Wang C, Han Z, Li G, Feng F, Li P^*, Chen L^*, Sun C^*. 2021. Exacerbated AIDS progression by PD-1 blockade during therapeutic vaccination in chronically SIV-infected rhesus macaques after ART treatment interruption. J Virol?96:e0178521
13. Li M^#, Yuan Y^#, Li P^#, Deng Z, Wen Z, Wang H, Feng F, Zou H, Chen L, Tang S^*, Sun C^*. 2022. Comparison of the Immunogenicity of HIV-1 CRF07_BC Gag Antigen With or Without a Seven Amino Acid Deletion in p6 Region. Front Immunol?13:850719.
14. Wu C, Zhao J, Li R, Feng F, He Y, Li Y, Huang R, Li G, Yang H, Cheng G, Chen L, Ma F, Li P^*, Sun C^*. 2021. Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques. Virol Sin?36(5):1197-1209
15. Yan Q^#, Li P^#, Ye X^#, Huang X^#, Feng B, Ji T, Chen Z, Li F, Zhang Y, Luo K, Chen F, Mo X, Wang J, Feng L, Hu F, Lei C^*, Qu L^*, Chen L^*. 2021. Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients. J Immunol 206:2146-2159.
16. Yang Q^#, Feng F^#, Li P^#, Pan E, Wu C, He Y, Zhang F, Zhao J, Li R, Feng L, Hu F, Li L, Zou H, Cai W, Lehner T*, Sun C*, Chen L*. 2019. Arsenic Trioxide Impacts Viral Latency and Delays Viral Rebound after Termination of ART in Chronically SIV-Infected Macaques. Adv Sci (Weinh)?6:1900319.
17. Zhang F, Wang L, Niu X, Li J, Luo J, Feng Y, Yang Y, He P, Fan W, Liang R, Zheng Z, Pan W, Li C, Tan YJ, Yu H, Chen L^*, Li P^*. 2019. Phenotypic Characterization of Chinese Rhesus Macaque Plasmablasts for Cloning Antigen-Specific Monoclonal Antibodies. Front Immunol?10:2426.
18. Li P, Feng F, Pan E, Fan X, Yang Q, Guan M, Chen L^*, Sun C^*. 2018. Scavenger receptor-mediated Ad5 entry and acLDL accumulation in monocytes/macrophages synergistically trigger innate responses against viral infection. Virology 519:86-98.
19. Wang X^#, Sun C^#, Li P, Wu T, Zhou H, Yang D, Liu Y, Ma X, Song Z, Nian Q, Feng L, Qin C*, Chen L*, Tang R*. 2016. Vaccine Engineering with Dual-Functional Mineral Shell: A Promising Strategy to Overcome Preexisting Immunity. Adv Mater?28:694-700.