2024年5月-，中國科學院廣州生物醫(yī)藥與健康研究院，副研究員

2021年7月-2024年4月，中國科學院廣州生物醫(yī)藥與健康研究院，助理研究員

2019年7月-2021年6月，中國科學院廣州生物醫(yī)藥與健康研究院，博士后/特別研究助理

2013年9月-2019年6月，中國科學技術大學，結(jié)構(gòu)生物學專業(yè)，生物學博士學位

?核受體家族蛋白的生理功能和調(diào)控的分子機制

1. 國家自然科學基金青年基金（2024），主持。

2. 呼吸疾病國家重點實驗室自主課題項目（2022年），主持。

3. 廣州市基礎與應用基礎研究基金（博士青年科技人員類項目）2021年，主持

1. Wang, N.#*, Sheng, Y.#, Liu, Y., Guo, Y., He, J., and Liu, J*. (2024) Cryo-EM structures of Mycobacterium tuberculosis polynucleotide phosphorylase suggest a potential mechanism for its RNA substrate degradation. ARCH BIOCHEM BIOPHYS 754, 109917.

2. Zhen, X., Gan, Q., Qu, L., Dong, Y., Pan, C., Liu, J., Wang, N.*, and Xu, T*. (2023) ERRγ-DBD undergoes dimerization and conformational rearrangement upon binding to the downstream site of the DR1 element. BIOCHEM BIOPH RES CO 656, 16-22.

3.? ? ? ? ?Chen, R., Francese, R., Wang, N., Li, F., Sun, X., Xu, B., Liu, J., Liu, Z., Donalisio, M., Lembo, D., and Zhou, G. C. (2023) Exploration of novel hexahydropyrrolo[1,2-e]imidazol-1-one derivatives as antiviral agents against ZIKV and USUV. Eur. J. Med. Chem 248, 115081.

4. Zhou, G. F., Qian, W., Li, F., Yang, R. H., Wang, N., Zheng, C. B., Li, C. Y., Gu, X. R., Yang, L. M., Liu, J., Xiong, S. D., Zhou, G. C., and Zheng, Y. T. (2023) Discovery of ZFD-10 of a pyridazino[4,5-b]indol-4(5H)-one derivative as an anti-ZIKV agent and a ZIKV NS5 RdRp inhibitor. ANTIVIR RES 214, 105607.

5. Zhao, M.#, Wang, N.#, Guo, Y.#, Li, J., Yin, Y., Dong, Y., Zhu, J., Peng, C., Xu, T.*, and Liu, J.* (2022) Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXRα heterodimer. PNAS 119, e2206737119.

6. Huang, T., Fu, X., Wang, N., Yang, M., Zhang, M., Wang, B., Chen, T., Majaz, S., Wang, H., Wong, C. W., Liu, J., and Guan, M. (2021) Andrographolide prevents bone loss via targeting estrogen-related receptor-α-regulated metabolic adaption of osteoclastogenesis. Br. J. Pharmacol 178, 4352-4367.

7. Zhang, M., Yang, M., Wang, N., Liu, Q., Wang, B., Huang, T., Tong, Y., Ming, Y., Wong, C. W., Liu, J., Yao, D., and Guan, M. (2020) Andrographolide modulates HNF4α activity imparting on hepatic metabolism. Mol. Cell. Endocrinol 513, 110867.

8. Wang, N., Zou, Q., Xu, J., Zhang, J., and Liu, J. (2018) Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding. JBC293, 18180-18191.

9. Njire, M., Wang, N., Wang, B., Tan, Y., Cai, X., Liu, Y., Mugweru, J., Guo, J., Hameed, H. M. A., Tan, S., Liu, J., Yew, W. W., Nuermberger, E., Lamichhane, G., Liu, J., and Zhang, T. (2017) Pyrazinoic Acid Inhibits a Bifunctional Enzyme in Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy 61.