教育經(jīng)歷（從大學開始填起）：

1999.09--2003.07:? 河南農(nóng)業(yè)大學?? 動物醫(yī)學系???? 學士

工作經(jīng)歷：??

2024.04--至今：中國科學院廣州生物醫(yī)藥與健康研究院? 高級實驗師

2011.03--2024.03：中國科學院廣州生物醫(yī)藥與健康研究院 助理研究員

2009.01--2011.02：廈門大學附屬演武醫(yī)院中心實驗室???? 實驗師

2003.07--2008.12：山東盛能奶牛高效繁育研發(fā)基地?? 助理實驗師

1.?動物克隆及基因編輯模式動物制備

2.?顯微操作技術(shù)應用

1. Yanhui Liang#,Jingke Xie#,Quanjun Zhang#,Xiaomin Wang#,Shixue Gou,Lihui Lin,Tao Chen,Weikai Ge,Zhenpeng Zhuang,Meng Lian,Fangbing Chen,Nan Li,Zhen Ouyang,Chengdan Lai,Xiaoyi Liu,Lei Li,Yinghua Ye,Han Wu,Kepin Wang*,and Liangxue Lai*. AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns. Nucleic Acids Research. 2022 May 20;50(9):5384–5399.

2. Quanmei Yan#,?Quanjun Zhang#,?Huaqiang Yang,?Qingjian Zou,Chengcheng Tang,Nana Fan*,Liangxue Lai*. Generation of multi-gene knockout rabbits using the Cas9/gRNA system. Cell Regeneration. 2014 Sep 27;3(1):12.

非第一作者論文

1. Jingke Xie#,Zhenpeng Zhuang#,Shixue Gou#,Quanjun Zhang,Xia Wang,Ting Lan,Meng Lian,Nan Li,Yanhui Liang,Zhen Ouyang,Yinghua Ye,Han Wu,Liangxue Lai*,Kepin Wang* . Precise genome editing of the Kozak sequence enables bidirectional and quantitative modulation of protein translation to anticipated levels without affecting transcription. Nucleic Acids Research. 2023 Oct 13;51(18):10075–10093.

2. Nan Li#,Shixue Gou#,Jiaowei Wang#,Quanjun Zhang,Xingyun Huang,Jingke Xie,Li Li,Qin Jin,Zhen Ouyang,Fangbing Chen,?Weikai Ge,Hui Shi,Yanhui Liang,Zhenpeng Zhuang,Xiaozhu Zhao,Meng Lian,Yinghua Ye,Longquan Quan,Han Wu*,Liangxue Lai*,Kepin Wang*. CRISPR/Cas9-mediated gene correction in newborn rabbits with hereditary tyrosinemia type I.?Molecular Therapy.2021 Mar,3;29(3):1001-1015.

3. Zhiquan Liu?#?,?Siyu Chen?#?,?Huanhuan Shan?,?Quanjun Zhang?,?Mao Chen?,?Liangxue Lai*?,?Zhanjun Li*?. Efficient and precise base editing in rabbits using humanAPOBEC3A-nCas9 fusions. Cell Discovery.2019 Jun 11;5:31.?

4. Yanling Zhu#,Zhishuai Zhang#,Nana Fan#,Ke Huang,Hao Li,Jiaming Gu,Quanjun Zhang,Zhen Ouyang,Tian Zhang,Jun Tang,Yanqi Zhang,Yangyang Suo,Chengdan Lai,Jiaowei Wang,Junwei Wang,Yongli Shan,Mingquan Wang,Qianyu Chen,Tiancheng Zhou,Liangxue Lai*，Guangjin Pan*. Generating functional cells through enhanced interspecies chimerism with human pluripotent stem cells. Stem Cell Reports. 2022 May 10;17(5):1059–1069.

5. ?Jingke Xie#;Weikai Ge#;?Nan Li#;Qishuai Liu#;Fangbing Chen;Xiaoyu Yang,Xingyun Huang;Zhen Ouyang;Quanjun Zhang;Yu Zhao;Zhaoming Liu;Shixue Gou;Han Wu;Chengdan Lai;Nana Fan;Qin Jin;Hui Shi;Yanhui Liang;Ting Lan;Longquan Quan;Xiaoping Li;Kepin Wang*;Liangxue Lai*;Efficient base editing for multiple genes/loci in pigs using base editors.?Nature Communications. 2019,June,10(1):2852.

6. ?Li L,Zhang Q,Yang H,Zou Q,Lai C,Zhao Ping,Luo Z,Yang J,Chen Q,Wang Y,Newsome P,Frampton J,Maxwell P. H.,Siu T,Tam S,Tse H,Qin B,Bao X,Esteban M*,and Lai L*. Fumarylacetoacetate hydrolase knockout rabbit model for hereditary tyrosinemia type 1.?J Biol Chem. 2017 Mar 17;292(11):4755-4763.

7. Wei S#,?Zou Q#,?Lai S#,?Zhang Q,?Li L,?Yan Q,?Zhou X,?Zhong H,?Lai L. Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators. Scientific Reports.?2016 Jan 19;6:19648.

Song J#,Zhong J#,Guo X#,Chen Y,Zou Q,Huang J,Li X,Zhang Q,Jiang Z,Tang C,Yang H,Liu T,Li P,Pei D*,Lai L*. Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs. Cell Research. 2013 Aug;23(8):1059-62.