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論文題目
Parallel Kinetic Resolution through Palladium-Catalyzed Enantioselective Cycloimidoylation: En Route to Divergent N-Heterocycles Bearing a Quaternary Stereogenic Center
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作者
Xilong Wang, Yu Luo, Jing Li, Chaoqin Wang, Qianwen Liu, Yimiao He, Shuang Luo* and Qiang Zhu
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論文出處
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刊物名稱
ACS Catalysis
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年卷期頁
2022, 12, , 14918-14925
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聯(lián)系作者
Qiang Zhu
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影響因子
13.700
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摘要
An example of a parallel kinetic resolution catalyzed by palladium to produce enantioenriched five- and six-membered N-heterocycles in one pot was developed. Dihydroisoquinolines and 1H-isoindoles containing a quaternary stereogenic center were obtained from racemic isocyanides in high yields with good enantioselectivities under mild conditions. A 6,6′-dipropyl substituted SPINOL-derived phosphoramidite was used as the chiral ligand for the palladium catalyst, resulting in regiodivergent and stereospecific cycloimidoylation. Density functional theory (DFT) calculations reveal the origin of the regio- and enantioselectivity during the C(sp2)？H imidoylative cyclization process. KEYWORDS: palladium catalysis, enantioselective imidoylation, parallel kinetic resolution, C？H activation, quaternary stereogenic center
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英文摘要
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